Centenary celebration

BC Centenary: A Celebration of Excellence in Research and Teaching
1921 – 2021
Online meeting: December 10 - 12, 2021
(Time zone : IST)

FIRST DAY – 10 December 2021

3:40 pm - 4 pm : WELCOME
Prof. P.N. RANGARAJAN, Chair, Dept. of Biochemistry, IISc
Release of Reminiscences book
Prof. GOVINDAN RANGARAJAN, Director, IISc

SESSION 1 – Synthetic Biology
Chair	Patrick D'Silva
4 - 4:30 pm	John Bowman, Monash University Why all eukaryotes have homeodomain genes
4:30 - 5 pm	Irene Coin, University of Leipzig Genetically encoded chemical tools for protein studies in the live cell
5 - 5:30 pm	Sarah Teichmann, Wellcome Sanger Institute Mapping The Human Body One Cell At A Time

BC Alumni / Student talks - I (10 min each)
Chairs	Saravanan Palani and Debabrata Laha
5:30 - 7 pm	Manoj Thakur, BC, IISc A Novel ATPase Associated with Holliday Junction Resolution in Mycobacterium tuberculosis
5:30 - 7 pm	Mitali Singh, Institut Pasteur, Paris Argonaute navigating the balance between protein translation and small RNA synthesis
5:30 - 7 pm	Devanjan Sinha, BHU Human Mitochondrial Presequence Translocases: From Machineries to Mechanisms
5:30 - 7 pm	Lekha E Manjunath, BC, IISc Stop codon readthrough in MTCH2 mRNA and its role in mitochondrial physiology
5:30 - 7 pm	Anubhav Dhar, BC, IISc Unravelling the spatio-temporal regulation of cell division proteins
5:30 - 7 pm	Naga Jyothi Pullagurla, BC, IISc Decoding the molecular basis of inositol phosphate homeostasis in plants

SESSION 2 – Cellular Biochemistry
Chair	D.N. Rao
7 - 7:30 pm	Hemalatha Balaram, JNCASR Metabolism in the malaria parasite, Plasmodium: essentiality of enzymes and pathways involved in fumarate anaplerosis across life stages
7:30 - 8 pm	AP Naren, Cedars-Sinai Medical Center From Macromolecular Complexes to Personalized Medicine in Cystic Fibrosis: Targeting Protein Interactions

8 - 9 pm: PLENARY TALK 1
Chair	K. Muniyappa
8 - 9 pm	Makkuni Jayaram, University of Texas The Bright and Dark Sides of Water: Promoting CRISPR Locus Assembly and Disrupting Site-Specific DNA Recombination

9 - 10 pm: PLENARY TALK 2
Chair	D.N. Rao
9 - 10 pm	Chaitan Khosla, Stanford University Mechanistic Principles of Assembly-Line Polyketide Biosynthesis

SECOND DAY – 11 December 2021

SESSION 3 – Reproductive Biology & Human Health
Chair	P. I. Rajyaguru
4 - 4:30 pm	Polani B. Seshagiri, IISc Embryonic steps towards development and differentiation of blastocysts
4:30 - 5 pm	Selvaraj Nataraja, Astellas Pharma Bench to Bedside: Translating Reproductive Research to Therapeutics in Women’s Health
5 - 5:30 pm	Surendra Sharma, Women and Infants Hospital-Brown University Our arduous research journey from preeclampsia to Alzheimer’s disease

BC Alumni / Student talks - II (10 min each)
Chairs	Mahipal Ganji and BICS Representative
5:30 - 7 pm	Swati Saha, University of Delhi Investigating epigenetic regulatory mechanisms in Leishmania donovani
5:30 - 7 pm	Trishna Dey, BC, IISc A novel methanol-free, glutamate-inducible yeast expression system
5:30 - 7 pm	Amrisha Bhosle, Broad Institute Title to be announced
5:30 - 7 pm	Deepash Kothiwal, Harvard Medical School Understanding the multi-level regulation of eukaryotic transcription: Insights from cohesin and RNA Pol II
5:30 - 7 pm	Raju Roy, BC, IISc RGG-motif protein Sbp1 is required for Processing body (P-body) disassembly
5:30 - 7 pm	Abhinav Banerjee, BC, IISc Scoping the DNA microcosm

SESSION 4– Genome Biology
Chair	Shikha Laloraya
7 - 7:30 pm	Harinder Singh, University of Pittsburgh Nature of combinatorial interactions of transcription factors underpinning the decoding of mammalian regulatory DNA
7:30 - 8 pm	Rachel Green, Johns Hopkins School of Medicine Colliding ribosomes function as key triggers for cellular stress response pathways

8 - 9 pm: PLENARY TALK 3
Chair	Nagasuma Chandra
8 - 9 pm	Janet Thornton, European Molecular Biology Laboratory (EMBL-EBI) Computational Enzymology: Enzyme Flexibility, Transformations and Mechanisms

9 - 10 pm: PLENARY TALK 4
Chair	Sandeep Eswarappa
9 - 10 pm	Vishva M. Dixit, Genentech Why so Many Ways to Die? The non-canonical Inflammasome Pathway

THIRD DAY – 12 December 2021

BC alumni talk – III
Chair	C. Jayabaskaran
4 - 4:30 pm	G Sudarshan, Institut Curie, Paris Insights into the structural and functional roles of tubulin posttranslational glycylation in mammalian cilia and flagella

BC Alumni / Student talks - IV (10 min each)
Chairs	Kesavardana Sannula and BICS representative
5:30 - 7 pm	Satpal Singh, BC, IISc The Enigma of Taxol Production by Taxol-Producing Endophytic Fungi: Lessons Learnt at the Laboratory of Secondary Metabolism
5:30 - 7 pm	Anujith Kumar, Manipal University Atypical Role of Antioxidant Enzyme SOD2 in Neural Lineage Specification
5:30 - 7 pm	Mridula Nambiar, IISER Pune Centromeric repression of recombination during meiosis - the how and the why
5:30 - 7 pm	Kumar Somyajit, University of Southern Denmark Metabolic control of human DNA replication dynamics in health and disease
5:30 - 7 pm	Sharath B, BC, IISc SARS-CoV-2 molecular mimicry in driving host cell death and inflammation

SESSION 5 - Immunology
Chair	Dipankar Nandi
5:45 – 6:15 pm	Sarah Gaffen, University of Pittsburgh IL-17 signaling in autoimmunity versus fungal immunity
6:15 -6:45 pm	Ali Ellebedy, Washington University B cell response to SARS-CoV-2
6:45 – 7 pm pm	BREAK

SESSION 6 : Translational / Disease Biology
Chair	N. Ganesh
7 – 7:30 pm	VR Prasad, Albert Einstein College of Medicine Extrinsic regulation of ESCRT factors, HIV-1 release and Replication Fitness by a b Chemokine
7:30 - 8 pm	Sandeep Burma, UT Southwestern Medical Center DNA Damage, Senescence, and Cancer

8 - 9 pm: PLENARY TALK 5
Chair	S. Mahadevan and P.N. Rangarajan
8 - 9 pm	James Westwood, Virginia Tech The parasitic plant dodder (Cuscuta) uses RNAs to manipulate its hosts

9 - 10 pm: PLENARY TALK 6
Chair	Sathees Raghavan
9 - 10 pm	Maria Jasin, Memorial Sloan Kettering, New York Protecting the genome by homologous recombination

10 - 10:15 pm - Vote of thanks by Dipankar Nandi,BICS President